UF study shows how cigarette smoke blocks cell repair

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Many smokers acknowledge that their risk for lung cancer goes up the longer they smoke. But new research finds that women should be aware smoking heightens their risk of developing breast cancer, too.

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A new study by University of Florida cell biologists suggests that cigarette smoke condensate, or c-s-c— a mixture of the four-thousand or so chemicals in a single puff— can contribute to the formation of breast cancer cells. The work was performed in a lab, in cell culture. U-F experts say they’ve pinpointed the method by which carcinogens from cigarettes can damage human DNA. The scientists say c-s-c can then activate a certain gene that prevents a key enzyme from orchestrating a cell’s internal repair mechanism.

Dr. Satya Narayan / UF cell biologist

“So in this case, in our study, we found that when we treat the cells with CSC –it is going to produce DNA damage.”

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U-F scientists say that if this damage is not repaired before cells divide, then corrupted copies can form that may turn cancerous over time. While the research is still at an early stage, experts say it’s important that smokers, as they enjoy a cigarette today, bear in mind the cumulative effect carcinogens could have decades down the road.

Dr. Satya Narayan / UF cell biologist

“We have to remember that we have to wait thirty, forty years before we can see effects. So much later on we can develop harmful effects, unwanted effects that we don’t want to see.”

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At the University of Florida Health Science Center…I’m Mike Garrison

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